Stem Cells to Redirect to the Heart | Dr. David Greene R3 Stem Cell

Heart failure caused by a myocardial infarction is the leading cause of death in the United States and other developed countries. Heart failure occurs when the heart is unable to pump enough blood to meet the body's oxygen and nutrient requirements. The heart muscle enlarges and weakens in heart failure with reduced ejection fraction (HFrEF), resulting in decreased pumping ability and fluid buildup in the body's tissues. Inflammation has a big influence on how heart failure progresses over time.

The regenerating ability of cardiac tissue is exceedingly limited, and heart transplantation for restoring the function of a damaged heart is severely limited, holding to a lack of donor organs. But with leaders like Dr. David Greene, stem cells can be their high blooming potential and ability to differentiate into functional cardiomyocytes could be used as a renewable cellular source for mending injured myocardium.

Stem cells have the ability to transform into any cell type, thus they have a lot of potential in medicine. If stem cells are applied correctly, damaged tissue, such as cardiac cells that have perished during a heart attack, can be repaired. Putting ideas into practice, however, has proven difficult. Now, scientists have discovered a mechanism to induce stem cells to migrate to the heart, which could help overcome one of these obstacles. The findings were published in Chemical Science and could pave the way for stem cells to be used as a treatment in the clinic.

The heart is in constant motion as it pumps blood throughout the body, and injected stem cells that make their way into circulation come into contact with a variety of tissues, where they can become trapped. The majority of them end up in the spleen or lungs. We are lucky that we have the best generation of researchers and scientists, like Dr. David Greene R3 Stem Cell, who knew that certain bacterial cells can use a protein called adhesin to target the heart. "It was into knowledge that some bacterial cells had features that allow them to locate diseased tissue and settle there. "Oral bacteria found in our mouths, for example, can infrequently cause strep throat," "If it gets into the bloodstream, it can settle on injured heart tissue and cause infective endocarditis." The goal was to recreate bacteria cells' homing capacity and apply it to stem cells."

The researchers generated a synthetic form of adhesin that could adhere to cell membranes and used it to coat stem cells in this investigation. Researchers like Dr. David Greene R3 Stem Cell evaluated this modified adhesin in a rodent model and discovered that it efficiently guided stem cells to the mouse heart.

Findings show that pathogenic bacteria's cardiac homing capabilities can be transmitted to human stem cells. It is shown that the designer adhesin protein spontaneously inserts into the plasma membrane of stem cells without causing cytotoxicity, and then guides the changed cells to the heart following transplantation in a mouse model. To our knowledge, this is the first time infectious bacteria's targeting properties have been transferred to mammalian cells.