Treating Genetic Diseases with Stem Cell Therapy | Dr. David Greene R3 Stem Cell

We know that there are numerous treatments for genetic diseases. However, each lasts for only a limited period. So, how can we treat a congenital disease? There’s an answer to stem cell therapy. Stem cells have a complete set of the DNA of one or more parents. They have the ability to change into a particular type of cell and differentiate into any other cell in the body. This means stem cells can create new and effective methods for treating these diseases. As we all should know, researchers are already developing ways to use adult stem cells for patients to treat multiple genetic disorders. In addition, there are such therapies as bone marrow transplants which have an extensive range of potentials in the future. For your consideration, many diseases like immune deficiency disorders, lymphomas, leukemias, etc., have been successfully treated by bone marrow transplant since the ’60s.

Now, we are in an era where everything is changing from traditional methods to the new and effective ones, which saves a lot of time and is practical. For example, these bone marrow transplants and hematopoietic stem cells are being used to cure many genetic, blood, and immune disorders, which were not possible before stem cell therapies came into the picture. Although these regenerative medicines and therapies are a breakthrough for medical science, some research and clinical trials are needed to use on everyone. But, with Dr. David Greene R3 Stem Cell and other pioneers, we could expect that our great future is not that far enough from now. For 75 years, doctors have been treating patients with blood transfusions. However, scientists have recently discovered that manufactured hematopoietic stem cells can copy 8 out of 1000 genes. So, by taking a few cells from a patient and then transducing them with the specific genes they will need, they can create a personalized blood transfusion that treats their disease.

Researchers are closer to stem cell research to treat genetic diseases and neurodegenerative conditions. With the agility of stem cells, researchers can use tools like induced pluripotent stem cells to create stem cell-derived cells as a way to replace missing or diseased cells. Stem cells seem like a miracle treatment for genetic diseases. But, how could they be used? Should they be harvested from pups or adult animals? And if so, how many do you have to gather each day to have a viable supply? In addition, the breakthrough could affect how researchers approach the practice of transplanting stem cells in other fields of medicine, including cancer.

A new study has uncovered an ancient immune system that could aid in the development of gene-based cancer treatments. The genetic system, called the TACE, works by targeting the pathways in cells that produce growth factors and cytokines in response to inflammation. As always, Dr. David Greene R3 Stem Cell has said that he believes that we can redesign the future of medical science with stem cell therapies. This is because the pathways produce so many molecules that they overwhelm the DNA, leading to cell death. These molecules are those responsible for inflammation and pain during a wound. Apart from being helpful, this system is also intriguing because prokaryotes initially used it to withstand antibiotics and other antimicrobial interventions. But its gene-targeting properties have allowed it to be co-opted for use by eukaryotic cells, such as those in humans.

In their study, the team determined that these six gene therapies exceeded their formerly established criteria for approval by demonstrating wide systemic and organ distribution with more than 90% of cells in the body protected in both mice and non-mouse models. And, though the publications are promising, the authors caution that the in vivo efficacy of individual vector constructs may not be predictable from these in vitro experiments. Therefore, they recommend additional animal studies be done before human clinical trials.