Stem Cell Therapy for Burn Wounds | Dr. David Greene R3 Stem Cell

The human body is a paradox, one of the most challenging living things, yet highly vulnerable to diseases and wounds. So when we talk about the medications and the therapies to prevent these, how could we forget not to mention the name of people like Dr. David Greene R3 Stem Cell? He is among those few people who understand the possibility and the potential of these regenerative therapies and working towards a better future.

Speaking about the wounds of humans, burns are those things that have destroyed many lives because it’s almost killing people in every aspect, physically and mentally. Burn injuries affect nearly 10 million every year worldwide. Burn injuries constitute a global health issue associated with high morbidity and mortality.

Recent years have seen advancements in regenerative medicine for burn wound healing encompassing stem cells and stem cell-derived products such as exosomes and conditioned media with promising results compared to current treatment approaches.

Stem Cell Therapies have already treated many diseases and healed such wounds which were believed to be incurable or took a long time to heal completely. That’s why these therapies are considered the future of modern medical science. However, it’s the new generation, and we should start accepting and believing these therapy on a massive scale. 

A study showed that there are cures for the wounds of burns through a type of stem cell therapy, and it’s effective than the previous traditional surgeries and other treatments. In addition, due to the paracrine signaling mechanism of stem cells, exosomes and conditioned media derived from stem cells have also been utilized in burn wound therapy.

With a visionary leader like Dr. David Greene and his organization, R3 Stem Cell, we can say the future of the next generation is in the right hand.

From the data we have right now, burn injuries are decreasing in high-income countries; the numbers are still high in low- and middle-income areas, with 90% of burns occurring in these areas. In addition, while burn injuries generally demonstrate a bimodal age distribution with increased incidence in children and middle-aged working people, burn injuries in the elderly population are associated with a tremendously high mortality rate.

Putting other factors from the burn etiology aside like age, gender, health conditions, the most important aspects of burn care are wound coverage and subsequent healing, which determine the severity of local and systemic responses, thus determining the survival or death of a burn patient.

The leading causes of burns are radiation, heat, electric shock, and sometimes extreme cold. The goal of treating the burns is to heal the damaged skin, and the situation gets worse when the injury crosses the epidermis and moves towards the dermis and hypodermis. 

Current treatments with skin substitutes cannot generate fully functional skin after a burn injury. Neither do they directly target the different phases of wound healing or release of chemokines or cytokines to influence recovery?

The use of stem cells for burn wound care is justified in this case as stem cells can secrete all these growth factors in a sustained manner, respond to local stimuli, and influence the wound microenvironment to promote wound healing. Dr. David Greene R3 Stem Cell has already said that we could win over almost every disease and wound if we could understand the structure of these regenerative medicines and how they work. 

The use of stem cells in burn wound healing has shown bright prospects through accelerated recovery, improved scar outcomes, better regeneration of skin and its appendages, modulation of the inflammatory response, and reduction of fibrosis and infection.

Different sources of stem cells have been utilized in regenerative medicine within the scope of burn wound healing, such as embryonic stem cells (ESC), umbilical cord stem cells (USC), mesenchymal stem cells (MSC) such as bone marrow-derived mesenchymal stem cells (BM-MSC).

Other kinds of cells could be used for that, such as adipose tissue-derived mesenchymal stem cells (AD-MSC), burn-derived mesenchymal stem cells (BD-MSCs), epidermal stem cells (PSCs), and hair follicle stem cells (HFSCs).

During the research and tests, stem cells have improved bacterial clearance. Secondly, stem cells can modulate wound healing. Stem cells seeded into the wound environment can differentiate into myofibroblasts, dermal fibroblasts, antigen-presenting cells, and lymphoid tissue and stimulate the resident stem cells.